Imprecision in Precision Medicine: Differential Response of a Disease-Linked GluN2A Mutant to NMDA Channel Blockers

Mutations in N-methyl-d-aspartate receptors (NMDAR) subunits have been implicated in a growing number of human neurodevelopmental disorders. Previously, a de novo mutation in GRIN2A, encoding the GluN2A subunit, was identified in a patient with severe epilepsy and developmental delay. This missense...

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Detalles Bibliográficos
Autores principales: Gale, Jenna R., Kosobucki, Gabrielle J., Hartnett-Scott, Karen A., Aizenman, Elias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581401/
https://www.ncbi.nlm.nih.gov/pubmed/34776984
http://dx.doi.org/10.3389/fphar.2021.773455

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581401/
https://www.ncbi.nlm.nih.gov/pubmed/34776984
http://dx.doi.org/10.3389/fphar.2021.773455

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