Cargando…

Exosome-mediated delivery of inflammation-responsive Il-10 mRNA for controlled atherosclerosis treatment

Rationale: Tailored inflammation control is badly needed for the treatment of kinds of inflammatory diseases, such as atherosclerosis. IL-10 is a potent anti-inflammatory cytokine, while systemic and repeated delivery could cause detrimental side-effects due to immune repression. In this study, we h...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bu, Te, Li, Zhelong, Hou, Ying, Sun, Wenqi, Zhang, Rongxin, Zhao, Lianbi, Wei, Mengying, Yang, Guodong, Yuan, Lijun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581418/ https://www.ncbi.nlm.nih.gov/pubmed/34815799 http://dx.doi.org/10.7150/thno.64229

Ejemplares similares

Ultrasound triggered topical delivery of Bmp7 mRNA for white fat browning induction via engineered smart exosomes
por: Guo, Yitong, et al.
Publicado: (2021)

Ultrasound Assisted Exosomal Delivery of Tissue Responsive mRNA for Enhanced Efficacy and Minimized Off-Target Effects
por: Sun, Wenqi, et al.
Publicado: (2020)

An optimized exosome production strategy for enhanced yield while without sacrificing cargo loading efficiency
por: Zhang, Rongxin, et al.
Publicado: (2022)

Improved extracellular vesicle-based mRNA delivery for familial hypercholesterolemia treatment
por: Yang, Zheng, et al.
Publicado: (2023)

Fusion protein engineered exosomes for targeted degradation of specific RNAs in lysosomes: a proof-of-concept study
por: Li, Zhelong, et al.
Publicado: (2020)

Efficient exosome delivery in refractory tissues assisted by ultrasound-targeted microbubble destruction
por: Sun, Wenqi, et al.
Publicado: (2019)

Targeted elimination of senescent cells by engineered extracellular vesicles attenuates atherosclerosis in ApoE(-/-) mice with minimal side effects
por: Zhang, Liang, et al.
Publicado: (2023)

Exosomes in atherosclerosis: performers, bystanders, biomarkers, and therapeutic targets
por: Wang, Chen, et al.
Publicado: (2021)

Exosome‐Based Mitochondrial Delivery of circRNA mSCAR Alleviates Sepsis by Orchestrating Macrophage Activation
por: Fan, Li, et al.
Publicado: (2023)

Mononuclear phagocyte system blockade improves therapeutic exosome delivery to the myocardium
por: Wan, Zhuo, et al.
Publicado: (2020)

Exosomes in atherosclerosis: Convergence on macrophages
por: Yang, Kaiying, et al.
Publicado: (2022)

Profibrogenic macrophage-targeted delivery of mitochondrial protector via exosome formula for alleviating pulmonary fibrosis
por: Zhang, Wei, et al.
Publicado: (2023)

Ultrasound Responsive Nanovaccine Armed with Engineered Cancer Cell Membrane and RNA to Prevent Foreseeable Metastasis
por: Sun, Wenqi, et al.
Publicado: (2023)

Adoptive transfer of metabolically reprogrammed macrophages for atherosclerosis treatment in diabetic ApoE(−/-) mice
por: Wang, Tingting, et al.
Publicado: (2022)

Therapeutic Effects of Simultaneous Delivery of Nerve Growth Factor mRNA and Protein via Exosomes on Cerebral Ischemia
por: Yang, Jialei, et al.
Publicado: (2020)

Hydrogel armed with Bmp2 mRNA-enriched exosomes enhances bone regeneration
por: Yang, Zhujun, et al.
Publicado: (2023)

Brown adipose tissue-derived exosomes mitigate the metabolic syndrome in high fat diet mice
por: Zhou, Xueying, et al.
Publicado: (2020)

Exosome-based Ldlr gene therapy for familial hypercholesterolemia in a mouse model
por: Li, Zhelong, et al.
Publicado: (2021)

A polyphenol-assisted IL-10 mRNA delivery system for ulcerative colitis
por: Chen, Zhejie, et al.
Publicado: (2022)

Chronic myelogenous leukemia cells remodel the bone marrow niche via exosome-mediated transfer of miR-320
por: Gao, Xiaotong, et al.
Publicado: (2019)

Multifaceted Roles of Adipose Tissue-Derived Exosomes in Physiological and Pathological Conditions
por: Liu, Yunnan, et al.
Publicado: (2021)

IL-10 mRNA Engineered MSCs Demonstrate Enhanced Anti-Inflammation in an Acute GvHD Model
por: Zhang, Cuiping, et al.
Publicado: (2021)

Exosomes for mRNA delivery: a novel biotherapeutic strategy with hurdles and hope
por: Aslan, Cynthia, et al.
Publicado: (2021)

The Role of IL-33 in the Inflammation Process of Asthma and Atherosclerosis
por: Fulgheri, Gabriele, et al.
Publicado: (2011)

Exosomes derived from reparative M2-like macrophages prevent bone loss in murine periodontitis models via IL-10 mRNA
por: Chen, Xutao, et al.
Publicado: (2022)

ROS triggered local delivery of stealth exosomes to tumors for enhanced chemo/photodynamic therapy
por: Wan, Zhuo, et al.
Publicado: (2022)

Molecular MRI of Inflammation in Atherosclerosis
por: te Boekhorst, Bernard C., et al.
Publicado: (2011)

Diagnostic and Prognostic Potential of Exosomal Cytokines IL-6 and IL-10 in Polytrauma Patients
por: Weber, Birte, et al.
Publicado: (2023)

Exosome-Based Treatment for Atherosclerosis
por: Heo, Jeongyeon, et al.
Publicado: (2022)

Platelet-Derived Exosomes in Atherosclerosis
por: Gardin, Chiara, et al.
Publicado: (2022)

Exercise Improves Metabolism and Alleviates Atherosclerosis via Muscle-Derived Extracellular Vesicles
por: Wang, Yixiao, et al.
Publicado: (2023)

Lipid nanoparticles for mRNA delivery
por: Hou, Xucheng, et al.
Publicado: (2021)

Macrophage Exosomes Resolve Atherosclerosis by Regulating Hematopoiesis and Inflammation via MicroRNA Cargo
por: Bouchareychas, Laura, et al.
Publicado: (2020)

Plasma-derived exosomal mRNA profiles associated with type 1 diabetes mellitus
por: Fan, Wenqi, et al.
Publicado: (2022)

Intracranial delivery of synthetic mRNA to suppress glioblastoma
por: Peng, Hao, et al.
Publicado: (2021)

Chlamydia pneumoniae Infection Induces Vascular Smooth Muscle Cell Migration and Atherosclerosis Through Mitochondrial Reactive Oxygen Species-Mediated JunB-Fra-1 Activation
por: Zhao, Xi, et al.
Publicado: (2022)

Regulatory T cells and IL-10 in allergic inflammation
por: Hawrylowicz, Catherine M.
Publicado: (2005)

Colon specific delivery of miR-155 inhibitor alleviates estrogen deficiency related phenotype via microbiota remodeling
por: Zhao, Lianbi, et al.
Publicado: (2022)

Zebrafish IL-4–like Cytokines and IL-10 Suppress Inflammation but Only IL-10 Is Essential for Gill Homeostasis
por: Bottiglione, Federica, et al.
Publicado: (2020)

Restoration of Motor Function through Delayed Intraspinal Delivery of Human IL-10-Encoding Nucleoside-Modified mRNA after Spinal Cord Injury
por: Gál, László, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ipv6778bo4jlc2shgb6gsm380g