Cargando…

CLEC-2-dependent platelet subendothelial accumulation by flow disturbance contributes to atherogenesis in mice

Rationale: Platelets play an essential role in atherosclerosis, but the underlying mechanisms remain to be addressed. This study is to investigate the role of platelets in d-flow induced vascular inflammation and the underlying mechanism. Methods: We established a disturbed blood flow (d-flow) model...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tang, Chaojun, Wang, Lei, Sheng, Yulan, Zheng, Zhong, Xie, Zhanli, Wu, Fan, You, Tao, Ren, Lijie, Xia, Lijun, Ruan, Changgeng, Zhu, Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581433/ https://www.ncbi.nlm.nih.gov/pubmed/34815786 http://dx.doi.org/10.7150/thno.64601

Ejemplares similares

THE SUBENDOTHELIAL SPACE IN CERTAIN ENDOCRINE TISSUES
por: Lever, J. D.
Publicado: (1956)

Platelets in Inflammation and Atherogenesis
por: Nording, Henry M., et al.
Publicado: (2015)

Kupffer cell receptor CLEC4F is important for the destruction of desialylated platelets in mice
por: Jiang, Yizhi, et al.
Publicado: (2021)

Fibulin-1 Integrates Subendothelial Extracellular Matrices and Contributes to Anatomical Closure of the Ductus Arteriosus
por: Ito, Satoko, et al.
Publicado: (2020)

Platelet CLEC‐2 and lung development
por: Suzuki‐Inoue, Katsue, et al.
Publicado: (2020)

The subendothelial extracellular matrix modulates NF-κB activation by flow: a potential role in atherosclerosis
por: Orr, A. Wayne, et al.
Publicado: (2005)

Platelets and Complement Cross-Talk in Early Atherogenesis
por: Kim, Hugh, et al.
Publicado: (2019)

Endothelium and Subendothelial Matrix Mechanics Modulate Cancer Cell Transendothelial Migration
por: Javanmardi, Yousef, et al.
Publicado: (2023)

Disturbed Flow Enhances Inflammatory Signaling and Atherogenesis by Increasing Thioredoxin-1 Level in Endothelial Cell Nuclei
por: Go, Young-Mi, et al.
Publicado: (2014)

Single-cell RNA-seq reveals cellular heterogeneity of mouse carotid artery under disturbed flow
por: Li, Fengchan, et al.
Publicado: (2021)

Platelet Adhesion to Podoplanin Under Flow is Mediated by the Receptor CLEC-2 and Stabilised by Src/Syk-Dependent Platelet Signalling
por: Navarro-Núñez, Leyre, et al.
Publicado: (2015)

Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo
por: Proebstl, Doris, et al.
Publicado: (2012)

Endothelial Cell Focal Adhesion Regulates Transendothelial Migration and Subendothelial Crawling of T Cells
por: Lee, Jaehyun, et al.
Publicado: (2018)

Endogenous Ceramide Contributes to the Transcytosis of oxLDL across Endothelial Cells and Promotes Its Subendothelial Retention in Vascular Wall
por: Li, Wenjing, et al.
Publicado: (2014)

Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2
por: Herzog, Brett H., et al.
Publicado: (2013)

Possible role of complement factor H in podocytes in clearing glomerular subendothelial immune complex deposits
por: Zoshima, Takeshi, et al.
Publicado: (2019)

Clustering extent‐dependent differential signaling by CLEC‐2 receptors in platelets
por: Dangelmaier, Carol, et al.
Publicado: (2022)

Divalent nanobodies to platelet CLEC-2 can serve as agonists or antagonists
por: Clark, Joanne C., et al.
Publicado: (2023)

Exosomes and Atherogenesis
por: Lin, Bingbing, et al.
Publicado: (2021)

Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2
por: Sung, Pei-Shan, et al.
Publicado: (2019)

Microfluidic model of monocyte extravasation reveals the role of hemodynamics and subendothelial matrix mechanics in regulating endothelial integrity
por: Pérez-Rodríguez, Sandra, et al.
Publicado: (2021)

Coalescent RNA-localizing and transcriptional activities of SAM68 modulate adhesion and subendothelial basement membrane assembly
por: Rekad, Zeinab, et al.
Publicado: (2023)

CLEC-2 Prevents Accumulation and Retention of Inflammatory Macrophages During Murine Peritonitis
por: Bourne, Joshua H., et al.
Publicado: (2021)

Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2
por: HUGHES, C E, et al.
Publicado: (2008)

Molecular Analysis of the Interaction of the Snake Venom Rhodocytin with the Platelet Receptor CLEC-2
por: Watson, Aleksandra A., et al.
Publicado: (2011)

Podoplanin-expressing inflammatory macrophages activate murine platelets via CLEC-2
por: Kerrigan, A M, et al.
Publicado: (2012)

TULA-2 Deficiency Enhances Platelet Functional Responses to CLEC-2 Agonists
por: Kostyak, John C., et al.
Publicado: (2018)

Low-dose Btk inhibitors selectively block platelet activation by CLEC-2
por: Nicolson, Phillip L.R., et al.
Publicado: (2020)

Katacine Is a New Ligand of CLEC-2 that Acts as a Platelet Agonist
por: Morán, Luis A., et al.
Publicado: (2022)

CLEC-2 Supports Platelet Aggregation in Mouse but not Human Blood at Arterial Shear
por: Bourne, Joshua H., et al.
Publicado: (2022)

Human Sinusoidal Subendothelial Cells Regulate Homing and Invasion of Circulating Metastatic Prostate Cancer Cells to Bone Marrow
por: Funari, Alessia, et al.
Publicado: (2019)

Subendothelial stiffness alters endothelial cell traction force generation while exerting a minimal effect on the transcriptome
por: Bastounis, Effie E., et al.
Publicado: (2019)

Atherogenesis: Initiating Factors
por: Waters, L. L.
Publicado: (1974)

Roles of Macrophages in Atherogenesis
por: Farahi, Lia, et al.
Publicado: (2021)

Humanin analogue, HNG, inhibits platelet activation and thrombus formation by stabilizing platelet microtubules
por: Ren, Lijie, et al.
Publicado: (2020)

Contribution of vascular cell-derived cytokines to innate and inflammatory pathways in atherogenesis
por: Loppnow, Harald, et al.
Publicado: (2011)

Platelet CLEC2-Podoplanin Axis as a Promising Target for Oral Cancer Treatment
por: Hwang, Byeong-Oh, et al.
Publicado: (2021)

Targeted subendothelial matrix oxidation by myeloperoxidase triggers myosin II-dependent de-adhesion and alters signaling in endothelial cells
por: Rees, Martin D., et al.
Publicado: (2012)

Identification of a novel platelet antagonist that binds to CLEC-2 and suppresses podoplanin-induced platelet aggregation and cancer metastasis
por: Chang, Yao-Wen, et al.
Publicado: (2015)

Vascular Smooth Muscle Cells Stimulate Platelets and Facilitate Thrombus Formation through Platelet CLEC-2: Implications in Atherothrombosis
por: Inoue, Osamu, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_u4b549ser6l27eib69a6cmfpo9