De novo peptide grafting to a self-assembling nanocapsule yields a hepatocyte growth factor receptor agonist

Lasso-grafting (LG) technology is a method for generating de novo biologics (neobiologics) by genetically implanting macrocyclic peptide pharmacophores, which are selected in vitro against a protein of interest, into loops of arbitrary protein scaffolds. In this study, we have generated a neo-capsid...

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Detalles Bibliográficos
Autores principales: Komatsu, Yamato, Terasaka, Naohiro, Sakai, Katsuya, Mihara, Emiko, Wakabayashi, Risa, Matsumoto, Kunio, Hilvert, Donald, Takagi, Junichi, Suga, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581506/
https://www.ncbi.nlm.nih.gov/pubmed/34805784
http://dx.doi.org/10.1016/j.isci.2021.103302

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581506/
https://www.ncbi.nlm.nih.gov/pubmed/34805784
http://dx.doi.org/10.1016/j.isci.2021.103302

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