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De novo peptide grafting to a self-assembling nanocapsule yields a hepatocyte growth factor receptor agonist
Lasso-grafting (LG) technology is a method for generating de novo biologics (neobiologics) by genetically implanting macrocyclic peptide pharmacophores, which are selected in vitro against a protein of interest, into loops of arbitrary protein scaffolds. In this study, we have generated a neo-capsid...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581506/ https://www.ncbi.nlm.nih.gov/pubmed/34805784 http://dx.doi.org/10.1016/j.isci.2021.103302 |