Human Bone Marrow Mesenchymal Stromal Cell-Derived Extracellular Vesicles Promote Proliferation of Degenerated Nucleus Pulposus Cells and the Synthesis of Extracellular Matrix Through the SOX4/Wnt/β-Catenin Axis

Objective: Intervertebral disk degeneration (IDD) is a major cause of pain in the back, neck, and radiculus. Mesenchymal stem cells (MSCs)-derived extracellular vesicles (EVs) are therapeutic in musculoskeletal degenerative diseases such as IDD. This study explored the effect and functional mechanis...

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Detalles Bibliográficos
Autores principales: Wang, Haoyu, Li, Fei, Ban, Wenrui, Zhang, Jing, Zhang, Guiqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581610/
https://www.ncbi.nlm.nih.gov/pubmed/34777000
http://dx.doi.org/10.3389/fphys.2021.723220

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581610/
https://www.ncbi.nlm.nih.gov/pubmed/34777000
http://dx.doi.org/10.3389/fphys.2021.723220

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