Melatonin enhances SIRT1 to ameliorate mitochondrial membrane damage by activating PDK1/Akt in granulosa cells of PCOS

Mitochondrial injury in granulosa cells (GCs) is associated with the pathophysiological mechanism of polycystic ovary syndrome (PCOS). Melatonin reduces the mitochondrial injury by enhancing SIRT1 (NAD-dependent deacetylase sirtuin-1), while the mechanism remains unclear. Mitochondrial membrane pote...

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Detalles Bibliográficos
Autores principales: Zheng, Bo, Meng, Junan, Zhu, Yuan, Ding, Min, Zhang, Yuting, Zhou, Jianjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582167/
https://www.ncbi.nlm.nih.gov/pubmed/34758863
http://dx.doi.org/10.1186/s13048-021-00912-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582167/
https://www.ncbi.nlm.nih.gov/pubmed/34758863
http://dx.doi.org/10.1186/s13048-021-00912-y

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