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An HSP90 cochaperone Ids2 maintains the stability of mitochondrial DNA and ATP synthase

BACKGROUND: Proteostasis unbalance and mitochondrial dysfunction are two hallmarks of aging. While the chaperone folds and activates its clients, it is the cochaperone that determines the specificity of the clients. Ids2 is an HSP90’s cochaperone controlling mitochondrial functions, but no in vivo c...

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Detalles Bibliográficos
Autores principales: Jiang, Pei-Heng, Hou, Chen-Yan, Teng, Shu-Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582188/
https://www.ncbi.nlm.nih.gov/pubmed/34763695
http://dx.doi.org/10.1186/s12915-021-01179-x