TGF-β protects osteosarcoma cells from chemotherapeutic cytotoxicity in a SDH/HIF1α dependent manner

BACKGROUND: In the widespread adoption of chemotherapy, drug resistance has been the major obstacle to tumor elimination in cancer patients. Our aim was to explore the role of TGF-β in osteosarcoma-associated chemoresistance. METHODS: We performed a cytotoxicity analysis of methotrexate (MTX) and ci...

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Detalles Bibliográficos
Autores principales: Xu, Yangbo, Li, Yafei, Chen, Xiaofan, Xiang, Feifan, Deng, Yong, Li, Zhong, Wei, Daiqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582194/
https://www.ncbi.nlm.nih.gov/pubmed/34763667
http://dx.doi.org/10.1186/s12885-021-08954-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582194/
https://www.ncbi.nlm.nih.gov/pubmed/34763667
http://dx.doi.org/10.1186/s12885-021-08954-7

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