Computational Analysis of the Mechanism of Nonenzymatic Peptide Bond Cleavage at the C-Terminal Side of an Asparagine Residue

[Image: see text] The nonenzymatic peptide bond cleavage at the C-terminal side of Asn residues is a protein post-translational modification that occurs under physiological conditions. This reaction proceeds much slower than the deamidation of the Asn side chain and causes denaturation and hypofunct...

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Detalles Bibliográficos
Autores principales: Kato, Koichi, Nakayoshi, Tomoki, Ishikawa, Yoshinobu, Kurimoto, Eiji, Oda, Akifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582265/
https://www.ncbi.nlm.nih.gov/pubmed/34778679
http://dx.doi.org/10.1021/acsomega.1c04821

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582265/
https://www.ncbi.nlm.nih.gov/pubmed/34778679
http://dx.doi.org/10.1021/acsomega.1c04821

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