Cargando…

CSF1R Inhibition Combined with GM-CSF Reprograms Macrophages and Disrupts Protumoral Interplays with AML Cells

SIMPLE SUMMARY: Acute myeloid leukemia is a blood disease whose long-term treatment is not satisfactory due to frequent (>50%) relapse despite complete initial remission. By adopting protumoral properties, macrophages in the leukemia cell microenvironment may promote resistance to treatment leadi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Smirnova, Tatiana, Spertini, Caroline, Spertini, Olivier
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582394/ https://www.ncbi.nlm.nih.gov/pubmed/34771453 http://dx.doi.org/10.3390/cancers13215289

Ejemplares similares

Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Downregulates the Expression of Protumor Factors Cyclooxygenase-2 and Inducible Nitric Oxide Synthase in a GM-CSF Receptor-Independent Manner in Cervical Cancer Cells
por: Jiang, Nanyan, et al.
Publicado: (2015)

GM-CSF impairs erythropoiesis by disrupting erythroblastic island formation via macrophages
por: Cao, Weijie, et al.
Publicado: (2022)

G-CSF and GM-CSF in clinical trials.
por: Antman, K. H.
Publicado: (1990)

GM-CSF in inflammation
por: Hamilton, John A.
Publicado: (2019)

GM-CSF Dependent Differential Control of Mycobacterium tuberculosis Infection in Human and Mouse Macrophages: Is Macrophage Source of GM-CSF Critical to Tuberculosis Immunity?
por: Mishra, Abhishek, et al.
Publicado: (2020)

Loss of GM-CSF-dependent instruction of alveolar macrophages in COVID-19 provides a rationale for inhaled GM-CSF treatment
por: Bosteels, Cedric, et al.
Publicado: (2022)

A role for G-CSF and GM-CSF in nonmyeloid cancers
por: Aliper, Alexander M, et al.
Publicado: (2014)

Recombinant GM-CSF for diseases of GM-CSF insufficiency: Correcting dysfunctional mononuclear phagocyte disorders
por: Lazarus, Hillard M., et al.
Publicado: (2023)

Acute Myeloid and Lymphoblastic Leukemia Cell Interactions with Endothelial Selectins: Critical Role of PSGL-1, CD44 and CD43
por: Spertini, Caroline, et al.
Publicado: (2019)

Heterogeneous GM-CSF signaling in macrophages is associated with control of Mycobacterium tuberculosis
por: Bryson, Bryan D., et al.
Publicado: (2019)

Neutrophil Extracellular Traps Reprogram IL-4/GM-CSF-Induced Monocyte Differentiation to Anti-inflammatory Macrophages
por: Guimarães-Costa, Anderson B., et al.
Publicado: (2017)

Rabbit M1 and M2 macrophages can be induced by human recombinant GM‐CSF and M‐CSF
por: Yamane, Kazuyoshi, et al.
Publicado: (2016)

Integrated transcriptomic and metabolomic analysis reveals the metabolic programming of GM-CSF- and M-CSF- differentiated mouse macrophages
por: Zhang, Qianyue, et al.
Publicado: (2023)

The effect of granulocyte-macrophage colony stimulating factor (rGM-CSF) on macrophage function in microbial disease
por: Jones, Thomas C.
Publicado: (1996)

GM-CSF-Dependent Inflammatory Pathways
por: Hamilton, John A.
Publicado: (2019)

Cxxc Finger Protein 1 Positively Regulates GM-CSF-Derived Macrophage Phagocytosis Through Csf2rα-Mediated Signaling
por: Hui, Zhaoyuan, et al.
Publicado: (2018)

Differential TLR7-mediated cytokine expression by R848 in M-CSF- versus GM-CSF-derived macrophages after LCMV infection
por: Alothaimeen, Torki, et al.
Publicado: (2020)

Development of Dendritic Cells from GM-CSF(-/-) Mice in vitro : GM-CSF Enhances Production and Survival of Cells
por: Ni, Keping, et al.
Publicado: (2001)

GM-CSF Protects Macrophages from DNA Damage by Inducing Differentiation
por: Vico, Tania, et al.
Publicado: (2022)

G‐CSF/GM‐CSF‐induced hematopoietic dysregulation in the progression of solid tumors
por: He, Kai, et al.
Publicado: (2022)

Blockade of collagen-induced arthritis post-onset by antibody to granulocyte-macrophage colony-stimulating factor (GM-CSF): requirement for GM-CSF in the effector phase of disease
por: Cook, Andrew D, et al.
Publicado: (2001)

Response to Treatment with TNFα Inhibitors in Rheumatoid Arthritis Is Associated with High Levels of GM-CSF and GM-CSF(+) T Lymphocytes
por: Bystrom, Jonas, et al.
Publicado: (2017)

Construction of Recombinant Human GM-CSF and GM-CSF-ApoA-I Fusion Protein and Evaluation of Their Biological Activity
por: Pykhtina, Mariya, et al.
Publicado: (2021)

M-CSF and GM-CSF Regulation of STAT5 Activation and DNA Binding in Myeloid Cell Differentiation is Disrupted in Nonobese Diabetic Mice
por: Rumore-Maton, B., et al.
Publicado: (2008)

G-CSF and GM-CSF Modify Neutrophil Functions at Concentrations found in Cystic Fibrosis
por: Castellani, Stefano, et al.
Publicado: (2019)

Roles of myeloperoxidase and GAPDH in interferon-gamma production of GM-CSF-dependent macrophages
por: Yamaguchi, Rui, et al.
Publicado: (2016)

Pivotal Roles of GM-CSF in Autoimmunity and Inflammation
por: Shiomi, Aoi, et al.
Publicado: (2015)

A Review of GM-CSF Therapy in Sepsis
por: Mathias, Brittany, et al.
Publicado: (2015)

The efficacy and safety of targeting GM-CSF in arthritis
por: Bykerk, Vivian P
Publicado: (2020)

GM-CSF: Orchestrating the Pulmonary Response to Infection
por: McCormick, Thomas S., et al.
Publicado: (2022)

Role of GM-CSF in lung balance and disease
por: Chen, Yingzi, et al.
Publicado: (2023)

Withholding of M-CSF Supplement Reprograms Macrophages to M2-Like via Endogenous CSF-1 Activation
por: Chen, Yu-Chih, et al.
Publicado: (2021)

Granulocyte-colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF) for sepsis: a meta-analysis
por: Bo, Lulong, et al.
Publicado: (2011)

GM-CSF Treated F4/80(+) BMCs Improve Murine Hind Limb Ischemia Similar to M-CSF Differentiated Macrophages
por: Kuwahara, Go, et al.
Publicado: (2014)

Glutamine Deprivation Promotes the Generation and Mobilization of MDSCs by Enhancing Expression of G-CSF and GM-CSF
por: Sun, Hong-Wei, et al.
Publicado: (2021)

Liver fibrosis and CD206(+) macrophage accumulation are suppressed by anti-GM-CSF therapy
por: Tan-Garcia, Alfonso, et al.
Publicado: (2019)

GM-CSF-activated STAT5A regulates macrophage functions and inflammation in atherosclerosis
por: Nagenborg, Jan, et al.
Publicado: (2023)

Recombinant human macrophage colony-stimulating factor (M-CSF) requires subliminal concentrations of granulocyte/macrophage (GM)-CSF for optimal stimulation of human macrophage colony formation in vitro
Publicado: (1987)

Methotrexate Provokes Disparate Folate Metabolism Gene Expression and Alternative Splicing in Ex Vivo Monocytes and GM-CSF- and M-CSF-Polarized Macrophages
por: Muller, Ittai B., et al.
Publicado: (2023)

Functional characterization of GM-CSF induced monocyte subsets
por: Däbritz, J, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_ortumkgribdtkun0suaoa7opkl