SMARCA4 Depletion Induces Cisplatin Resistance by Activating YAP1-Mediated Epithelial-to-Mesenchymal Transition in Triple-Negative Breast Cancer

SIMPLE SUMMARY: SMARCA4 mutations were over-representative in cisplatin resistance and metastatic triple-negative breast cancer (TNBC). Additionally, SMARCA4 inactivation induced the mesenchymal-like subtype TNBC. The epithelial-to-mesenchymal transition and Hippo-YAP/TAZ pathways were activated in...

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Detalles Bibliográficos
Autores principales: Kim, Jihyun, Jang, Gyubeom, Sim, Sung Hoon, Park, In Hae, Kim, Kyungtae, Park, Charny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582548/
https://www.ncbi.nlm.nih.gov/pubmed/34771636
http://dx.doi.org/10.3390/cancers13215474

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582548/
https://www.ncbi.nlm.nih.gov/pubmed/34771636
http://dx.doi.org/10.3390/cancers13215474

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