The C-Circle Biomarker Is Secreted by Alternative-Lengthening-of-Telomeres Positive Cancer Cells inside Exosomes and Provides a Blood-Based Diagnostic for ALT Activity

SIMPLE SUMMARY: A clinical test for alternative-lengthening-of-telomeres (ALT) could assist with cancer diagnosis and monitoring of disease progression. ALT-targeted anticancer treatments are being developed; however, there is no appropriate companion ALT diagnostic. The C-Circle biomarker is the on...

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Detalles Bibliográficos
Autores principales: Chen, Yuan-Yin, Dagg, Rebecca, Zhang, Yuchen, Lee, Joyce H. Y., Lu, Robert, Martin La Rotta, Nancy, Sampl, Sandra, Korkut-Demirbaş, Medina, Holzmann, Klaus, Lau, Loretta M. S., Reddel, Roger R., Henson, Jeremy D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582556/
https://www.ncbi.nlm.nih.gov/pubmed/34771533
http://dx.doi.org/10.3390/cancers13215369

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582556/
https://www.ncbi.nlm.nih.gov/pubmed/34771533
http://dx.doi.org/10.3390/cancers13215369

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