New Therapeutic Strategy for Overcoming Multidrug Resistance in Cancer Cells with Pyrazolo[3,4-d]pyrimidine Tyrosine Kinase Inhibitors

SIMPLE SUMMARY: P-glycoprotein (P-gp) is an ATP-binding cassette transporter whose overexpression in cancer cells is one of the main causes of multidrug resistance (MDR). Tyrosine kinase inhibitors (TKIs) have been reported to interact with ABC transporters and in some cases, increase the susceptibi...

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Detalles Bibliográficos
Autores principales: Podolski-Renić, Ana, Dinić, Jelena, Stanković, Tijana, Tsakovska, Ivanka, Pajeva, Ilza, Tuccinardi, Tiziano, Botta, Lorenzo, Schenone, Silvia, Pešić, Milica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582576/
https://www.ncbi.nlm.nih.gov/pubmed/34771471
http://dx.doi.org/10.3390/cancers13215308

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582576/
https://www.ncbi.nlm.nih.gov/pubmed/34771471
http://dx.doi.org/10.3390/cancers13215308

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