Bayesian Design for Identifying Cohort-Specific Optimal Dose Combinations Based on Multiple Endpoints: Application to a Phase I Trial in Non-Small Cell Lung Cancer

Immunotherapy and chemotherapy combinations have proven to be a safe and efficacious treatment approach in multiple settings. However, it is not clear whether approved doses of chemotherapy developed to achieve a maximum tolerated dose are the ideal dose when combining cytotoxic chemotherapy with im...

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Detalles Bibliográficos
Autores principales: Horton, Bethany Jablonski, Wages, Nolan A., Gentzler, Ryan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582706/
https://www.ncbi.nlm.nih.gov/pubmed/34769970
http://dx.doi.org/10.3390/ijerph182111452

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582706/
https://www.ncbi.nlm.nih.gov/pubmed/34769970
http://dx.doi.org/10.3390/ijerph182111452

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