Targeting DDX3X Helicase Activity with BA103 Shows Promising Therapeutic Effects in Preclinical Glioblastoma Models

SIMPLE SUMMARY: In the last ten years, the human helicase protein DDX3X turned out to be an extremely interesting target for the development of potential anticancer drugs. Herein, we discovered BA103, a novel specific inhibitor of the helicase binding site of DDX3X, which is characterized by broad-s...

Descripción completa

Detalles Bibliográficos
Autores principales: Brai, Annalaura, Riva, Valentina, Clementi, Letizia, Falsitta, Lucia, Zamperini, Claudio, Sinigiani, Virginia, Festuccia, Claudio, Sabetta, Samantha, Aiello, Davide, Roselli, Camilla, Garbelli, Anna, Trivisani, Claudia Immacolata, Maccari, Laura, Bugli, Francesca, Sanguinetti, Maurizio, Calandro, Pierpaolo, Chiariello, Mario, Quaranta, Paola, Botta, Lorenzo, Angelucci, Adriano, Maga, Giovanni, Botta, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582824/
https://www.ncbi.nlm.nih.gov/pubmed/34771731
http://dx.doi.org/10.3390/cancers13215569

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582824/
https://www.ncbi.nlm.nih.gov/pubmed/34771731
http://dx.doi.org/10.3390/cancers13215569

Ejemplares similares