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Bulges control pri-miRNA processing in a position and strand-dependent manner

MicroRNAs (miRNAs) play critical roles in gene expression and numerous human diseases. The success of miRNA biogenesis is largely determined by the primary miRNA (pri-miRNA) processing by the DROSHA-DGCR8 complex, called Microprocessor. Here, we analysed the high-throughput pri-miRNA processing assa...

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Detalles Bibliográficos
Autores principales: Li, Shaohua, Le, Thi Nhu-Y, Nguyen, Trung Duc, Trinh, Tam Anh, Nguyen, Tuan Anh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582997/
https://www.ncbi.nlm.nih.gov/pubmed/33382955
http://dx.doi.org/10.1080/15476286.2020.1868139