Differences in human IgG1 and IgG4 S228P monoclonal antibodies viscosity and self-interactions: Experimental assessment and computational predictions of domain interactions

Human/humanized IgG4 antibodies have reduced effector function relative to IgG1 antibodies, which is desirable for certain therapeutic purposes. However, the developability and biophysical properties for IgG4 antibodies are not well understood. This work focuses on the head-to-head comparison of key...

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Detalles Bibliográficos
Autores principales: Lai, Pin-Kuang, Ghag, Gaurav, Yu, Yao, Juan, Veronica, Fayadat-Dilman, Laurence, Trout, Bernhardt L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583000/
https://www.ncbi.nlm.nih.gov/pubmed/34747330
http://dx.doi.org/10.1080/19420862.2021.1991256

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583000/
https://www.ncbi.nlm.nih.gov/pubmed/34747330
http://dx.doi.org/10.1080/19420862.2021.1991256

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