Drug Repositioning Based on the Reversal of Gene Expression Signatures Identifies TOP2A as a Therapeutic Target for Rectal Cancer

SIMPLE SUMMARY: Rectal cancer is the 8th most common cancer globally. Most patients with locally advanced rectal cancer receive neoadjuvant therapy based on 5-fluorouracil and radiotherapy showing variable responses. About 70–90% of patients present partial response, while 20% show treatment resista...

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Detalles Bibliográficos
Autores principales: Carvalho, Robson Francisco, do Canto, Luisa Matos, Cury, Sarah Santiloni, Frøstrup Hansen, Torben, Jensen, Lars Henrik, Rogatto, Silvia Regina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583090/
https://www.ncbi.nlm.nih.gov/pubmed/34771654
http://dx.doi.org/10.3390/cancers13215492

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583090/
https://www.ncbi.nlm.nih.gov/pubmed/34771654
http://dx.doi.org/10.3390/cancers13215492

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