Activation of a Ductal-to-Endocrine Transdifferentiation Transcriptional Program in the Pancreatic Cancer Cell Line PANC-1 Is Controlled by RAC1 and RAC1b through Antagonistic Regulation of Stemness Factors

SIMPLE SUMMARY: For patients with metastatic pancreatic ductal adenocarcinoma (PDAC) there is currently no cure; hence, novel effective therapies are desperately needed. Among PDAC patients, the tumor cell phenotypes are heterogeneous as a result of epithelial–mesenchymal transition, a process that...

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Detalles Bibliográficos
Autores principales: Schmidtlein, Paula Marie, Volz, Clara, Hackel, Alexander, Thürling, Isabel, Castven, Darko, Braun, Rüdiger, Wellner, Ulrich Friedrich, Konukiewitz, Björn, Riemekasten, Gabriela, Lehnert, Hendrik, Marquardt, Jens-Uwe, Ungefroren, Hendrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583136/
https://www.ncbi.nlm.nih.gov/pubmed/34771704
http://dx.doi.org/10.3390/cancers13215541

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583136/
https://www.ncbi.nlm.nih.gov/pubmed/34771704
http://dx.doi.org/10.3390/cancers13215541

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