Activation of Hypoxia-Inducible Factor-1α Signaling Pathway Has the Protective Effect of Intervertebral Disc Degeneration

Intervertebral discs (IVDs) have poor nutrient diffusion, because the nucleus pulposus (NP) lacks direct vascular supply and likely generates adenosine triphosphate by anaerobic glycolysis. Regulation of glycolysis is mediated by hypoxia-inducible factor-1α (HIF-1α), a transcription factor that resp...

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Detalles Bibliográficos
Autores principales: Kim, Jin-Woo, An, Hyun-Ju, Yeo, HyunJeong, Jeong, Yunhui, Lee, HyeonHae, Lee, Jusung, Nam, Kisik, Lee, Jongheon, Shin, Dong-Eun, Lee, Soonchul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583205/
https://www.ncbi.nlm.nih.gov/pubmed/34768786
http://dx.doi.org/10.3390/ijms222111355

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583205/
https://www.ncbi.nlm.nih.gov/pubmed/34768786
http://dx.doi.org/10.3390/ijms222111355

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