Inhibiting Lysine Demethylase 1A Improves L1CAM-Specific CAR T Cell Therapy by Unleashing Antigen-Independent Killing via the FAS-FASL Axis

SIMPLE SUMMARY: Solid tumor cells can lose or heterogeneously express antigens to become resistant to chimeric antigen receptor (CAR) T cell therapy. Here, we explore whether epigenetic manipulation to unleash antigen-independent killing mechanisms can overcome this hurdle. KDM1A is overexpressed in...

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Detalles Bibliográficos
Autores principales: Sulejmani, Ornela, Grunewald, Laura, Andersch, Lena, Schwiebert, Silke, Klaus, Anika, Winkler, Annika, Astrahantseff, Kathy, Eggert, Angelika, Henssen, Anton G., Schulte, Johannes H., Anders, Kathleen, Künkele, Annette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583435/
https://www.ncbi.nlm.nih.gov/pubmed/34771652
http://dx.doi.org/10.3390/cancers13215489

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583435/
https://www.ncbi.nlm.nih.gov/pubmed/34771652
http://dx.doi.org/10.3390/cancers13215489

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