MicroRNA-21 Plays Multiple Oncometabolic Roles in Colitis-Associated Carcinoma and Colorectal Cancer via the PI3K/AKT, STAT3, and PDCD4/TNF-α Signaling Pathways in Zebrafish

SIMPLE SUMMARY: The PI3K/AKT, STAT3, and PDCD4/TNF-α signaling networks, regulated by the microRNA (miR)-21, are critical for inflammatory regulation, tumor suppressor modulation, and oncogenic activation. We developed a zebrafish model (ImiR-21) with an inducible overexpression of miR-21, specifica...

Descripción completa

Detalles Bibliográficos
Autores principales: Lai, Chi-Yu, Yeh, Kun-Yun, Liu, Bi-Feng, Chang, Tzu-Ming, Chang, Chuan-Hsun, Liao, Yung-Feng, Liu, Yi-Wen, Her, Guor Mour
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583575/
https://www.ncbi.nlm.nih.gov/pubmed/34771727
http://dx.doi.org/10.3390/cancers13215565

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583575/
https://www.ncbi.nlm.nih.gov/pubmed/34771727
http://dx.doi.org/10.3390/cancers13215565

Ejemplares similares