Comprehensive Identification of Deleterious TP53 Missense VUS Variants Based on Their Impact on TP53 Structural Stability

TP53 plays critical roles in maintaining genome stability. Deleterious genetic variants damage the function of TP53, causing genome instability and increased cancer risk. Of the large quantity of genetic variants identified in TP53, however, many remain functionally unclassified as variants of unkno...

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Detalles Bibliográficos
Autores principales: Tam, Benjamin, Sinha, Siddharth, Qin, Zixin, Wang, San Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583684/
https://www.ncbi.nlm.nih.gov/pubmed/34768775
http://dx.doi.org/10.3390/ijms222111345

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583684/
https://www.ncbi.nlm.nih.gov/pubmed/34768775
http://dx.doi.org/10.3390/ijms222111345

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