Novel Dual PI3K/mTOR Inhibitor, Apitolisib (GDC-0980), Inhibits Growth and Induces Apoptosis in Human Glioblastoma Cells

Deregulated PI3K/AKT/mTOR signalling commonly exists in glioblastoma, making this axis an attractive target for therapeutic manipulation. Given that activation of PI3K/AKT/mTOR promotes tumour growth, metastasis, and resistance to anticancer therapies, mTOR inhibitors show promise in the treatment o...

Descripción completa

Detalles Bibliográficos
Autores principales: Omeljaniuk, Wioleta Justyna, Krętowski, Rafał, Ratajczak-Wrona, Wioletta, Jabłońska, Ewa, Cechowska-Pasko, Marzanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583746/
https://www.ncbi.nlm.nih.gov/pubmed/34768941
http://dx.doi.org/10.3390/ijms222111511

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583746/
https://www.ncbi.nlm.nih.gov/pubmed/34768941
http://dx.doi.org/10.3390/ijms222111511

Ejemplares similares