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Novel Dual PI3K/mTOR Inhibitor, Apitolisib (GDC-0980), Inhibits Growth and Induces Apoptosis in Human Glioblastoma Cells

Deregulated PI3K/AKT/mTOR signalling commonly exists in glioblastoma, making this axis an attractive target for therapeutic manipulation. Given that activation of PI3K/AKT/mTOR promotes tumour growth, metastasis, and resistance to anticancer therapies, mTOR inhibitors show promise in the treatment o...

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Detalles Bibliográficos
Autores principales:	Omeljaniuk, Wioleta Justyna, Krętowski, Rafał, Ratajczak-Wrona, Wioletta, Jabłońska, Ewa, Cechowska-Pasko, Marzanna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583746/ https://www.ncbi.nlm.nih.gov/pubmed/34768941 http://dx.doi.org/10.3390/ijms222111511

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