Oxidative Transformations of 3,4-Dihydroxyphenylacetaldehyde Generate Potential Reactive Intermediates as Causative Agents for Its Neurotoxicity

Neurogenerative diseases, such as Parkinson’s disease, are associated, not only with the selective loss of dopamine (DA), but also with the accumulation of reactive catechol-aldehyde, 3,4-dihydroxyphenylacetaldehyde (DOPAL), which is formed as the immediate oxidation product of cytoplasmic DA by mon...

Descripción completa

Detalles Bibliográficos
Autores principales: Ito, Shosuke, Tanaka, Hitomi, Ojika, Makoto, Wakamatsu, Kazumasa, Sugumaran, Manickam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583873/
https://www.ncbi.nlm.nih.gov/pubmed/34769179
http://dx.doi.org/10.3390/ijms222111751

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583873/
https://www.ncbi.nlm.nih.gov/pubmed/34769179
http://dx.doi.org/10.3390/ijms222111751

Ejemplares similares