Increased Post-Hypoxic Oxidative Stress and Activation of the PERK Branch of the UPR in Trap1-Deficient Drosophila melanogaster Is Abrogated by Metformin

Hypoxia is known to impair mitochondrial and endoplasmic reticulum (ER) homeostasis. Post-hypoxic perturbations of the ER proteostasis result in the accumulation of misfolded/unfolded proteins leading to the activation of the Unfolded Protein Response (UPR). Mitochondrial chaperone TNF receptor-asso...

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Detalles Bibliográficos
Autores principales: Kokott-Vuong, Alma, Jung, Jennifer, Fehr, Aaron T., Kirschfink, Nele, Noristani, Rozina, Voigt, Aaron, Reich, Arno, Schulz, Jörg B., Huber, Michael, Habib, Pardes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583878/
https://www.ncbi.nlm.nih.gov/pubmed/34769067
http://dx.doi.org/10.3390/ijms222111586

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583878/
https://www.ncbi.nlm.nih.gov/pubmed/34769067
http://dx.doi.org/10.3390/ijms222111586

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