Structural and Functional Characterization of OXA-48: Insight into Mechanism and Structural Basis of Substrate Recognition and Specificity

Class D β-lactamase OXA-48 is widely distributed among Gram-negative bacteria and is an important determinant of resistance to the last-resort carbapenems. Nevertheless, the detailed mechanism by which this β-lactamase hydrolyzes its substrates remains poorly understood. In this study, the complex s...

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Detalles Bibliográficos
Autores principales: Chiou, Jiachi, Cheng, Qipeng, Shum, Perry Tim-fat, Wong, Marcus Ho-yin, Chan, Edward Wai-chi, Chen, Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583920/
https://www.ncbi.nlm.nih.gov/pubmed/34768916
http://dx.doi.org/10.3390/ijms222111480

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583920/
https://www.ncbi.nlm.nih.gov/pubmed/34768916
http://dx.doi.org/10.3390/ijms222111480

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