Design, synthesis, and biological evaluation of novel triazoloquinazolinone derivatives as SHP2 protein inhibitors

A novel series of triazoloquinazolinone derivatives were designed, synthesised, and evaluated for their in vitro biological activities against the SHP2 protein. Moreover, some compounds were evaluated against A375 cells. The results revealed that target compounds possessed moderate to excellent inhi...

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Detalles Bibliográficos
Autores principales: Luo, Rongshuang, Wang, Zhongyuan, Luo, Dali, Qin, Yumei, Zhao, Chunshen, Yang, Di, Lu, Tian, Zhou, Zhixu, Huang, Zhuyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583937/
https://www.ncbi.nlm.nih.gov/pubmed/34749564
http://dx.doi.org/10.1080/14756366.2021.1986491

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583937/
https://www.ncbi.nlm.nih.gov/pubmed/34749564
http://dx.doi.org/10.1080/14756366.2021.1986491

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