15d-PGJ(2) Promotes ROS-Dependent Activation of MAPK-Induced Early Apoptosis in Osteosarcoma Cell In Vitro and in an Ex Ovo CAM Assay

Osteosarcoma (OS) is the most common type of bone tumor, and has limited therapy options. 15-Deoxy-Δ(12,14)-prostaglandin J(2) (15d-PGJ(2)) has striking anti-tumor effects in various tumors. Here, we investigated molecular mechanisms that mediate anti-tumor effects of 15d-PGJ(2) in different OS cell...

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Detalles Bibliográficos
Autores principales: Mikulčić, Mateja, Tabrizi-Wizsy, Nassim Ghaffari, Bernhart, Eva M., Asslaber, Martin, Trummer, Christopher, Windischhofer, Werner, Sattler, Wolfgang, Malle, Ernst, Hrzenjak, Andelko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583949/
https://www.ncbi.nlm.nih.gov/pubmed/34769194
http://dx.doi.org/10.3390/ijms222111760

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583949/
https://www.ncbi.nlm.nih.gov/pubmed/34769194
http://dx.doi.org/10.3390/ijms222111760

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