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Hydroxylation of the Acetyltransferase NAA10 Trp38 Is Not an Enzyme-Switch in Human Cells

NAA10 is a major N-terminal acetyltransferase (NAT) that catalyzes the cotranslational N-terminal (Nt-) acetylation of 40% of the human proteome. Several reports of lysine acetyltransferase (KAT) activity by NAA10 exist, but others have not been able to find any NAA10-derived KAT activity, the latte...

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Detalles Bibliográficos
Autores principales: Ree, Rasmus, Krogstad, Karoline, McTiernan, Nina, Jakobsson, Magnus E., Arnesen, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583962/
https://www.ncbi.nlm.nih.gov/pubmed/34769235
http://dx.doi.org/10.3390/ijms222111805