Interference on Cytosolic DNA Activation Attenuates Sepsis Severity: Experiments on Cyclic GMP–AMP Synthase (cGAS) Deficient Mice

Although the enhanced responses against serum cell-free DNA (cfDNA) in cases of sepsis—a life-threatening organ dysfunction due to systemic infection—are understood, the influence of the cytosolic DNA receptor cGAS (cyclic guanosine monophosphate–adenosine monophosphate (GMP–AMP) synthase) on sepsis...

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Detalles Bibliográficos
Autores principales: Visitchanakun, Peerapat, Kaewduangduen, Warerat, Chareonsappakit, Awirut, Susantitaphong, Paweena, Pisitkun, Prapaporn, Ritprajak, Patcharee, Townamchai, Natavudh, Leelahavanichkul, Asada
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583992/
https://www.ncbi.nlm.nih.gov/pubmed/34768881
http://dx.doi.org/10.3390/ijms222111450

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583992/
https://www.ncbi.nlm.nih.gov/pubmed/34768881
http://dx.doi.org/10.3390/ijms222111450

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