Cell-Permeable Succinate Rescues Mitochondrial Respiration in Cellular Models of Amiodarone Toxicity

Amiodarone is a potent antiarrhythmic drug and displays substantial liver toxicity in humans. It has previously been demonstrated that amiodarone and its metabolite (desethylamiodarone, DEA) can inhibit mitochondrial function, particularly complexes I (CI) and II (CII) of the electron transport syst...

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Detalles Bibliográficos
Autores principales: Bețiu, Alina M., Chamkha, Imen, Gustafsson, Ellen, Meijer, Elna, Avram, Vlad F., Åsander Frostner, Eleonor, Ehinger, Johannes K., Petrescu, Lucian, Muntean, Danina M., Elmér, Eskil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583998/
https://www.ncbi.nlm.nih.gov/pubmed/34769217
http://dx.doi.org/10.3390/ijms222111786

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583998/
https://www.ncbi.nlm.nih.gov/pubmed/34769217
http://dx.doi.org/10.3390/ijms222111786

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