Autoantibodies from Patients with Scleroderma Renal Crisis Promote PAR-1 Receptor Activation and IL-6 Production in Endothelial Cells

Background. Scleroderma renal crisis (SRC) is a life-threatening complication of systemic sclerosis (SSc). Autoantibodies (Abs) against endothelial cell antigens have been implicated in SSc and SRC. However, their detailed roles remain poorly defined. Pro-inflammatory cytokine interleukin-6 (IL-6) h...

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Detalles Bibliográficos
Autores principales: Simon, Michèle, Lücht, Christian, Hosp, Isa, Zhao, Hongfan, Wu, Dashan, Heidecke, Harald, Witowski, Janusz, Budde, Klemens, Riemekasten, Gabriela, Catar, Rusan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584031/
https://www.ncbi.nlm.nih.gov/pubmed/34769227
http://dx.doi.org/10.3390/ijms222111793

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584031/
https://www.ncbi.nlm.nih.gov/pubmed/34769227
http://dx.doi.org/10.3390/ijms222111793

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