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PARP-1-Associated Pathological Processes: Inhibition by Natural Polyphenols
Poly (ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme involved in processes of cell cycle regulation, DNA repair, transcription, and replication. Hyperactivity of PARP-1 induced by changes in cell homeostasis promotes development of chronic pathological processes leading to cell death during v...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584120/ https://www.ncbi.nlm.nih.gov/pubmed/34768872 http://dx.doi.org/10.3390/ijms222111441 |
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author | Maluchenko, Natalya V. Feofanov, Alexey V. Studitsky, Vasily M. |
author_facet | Maluchenko, Natalya V. Feofanov, Alexey V. Studitsky, Vasily M. |
author_sort | Maluchenko, Natalya V. |
collection | PubMed |
description | Poly (ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme involved in processes of cell cycle regulation, DNA repair, transcription, and replication. Hyperactivity of PARP-1 induced by changes in cell homeostasis promotes development of chronic pathological processes leading to cell death during various metabolic disorders, cardiovascular and neurodegenerative diseases. In contrast, tumor growth is accompanied by a moderate activation of PARP-1 that supports survival of tumor cells due to enhancement of DNA lesion repair and resistance to therapy by DNA damaging agents. That is why PARP inhibitors (PARPi) are promising agents for the therapy of tumor and metabolic diseases. A PARPi family is rapidly growing partly due to natural polyphenols discovered among plant secondary metabolites. This review describes mechanisms of PARP-1 participation in the development of various pathologies, analyzes multiple PARP-dependent pathways of cell degeneration and death, and discusses representative plant polyphenols, which can inhibit PARP-1 directly or suppress unwanted PARP-dependent cellular processes. |
format | Online Article Text |
id | pubmed-8584120 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85841202021-11-12 PARP-1-Associated Pathological Processes: Inhibition by Natural Polyphenols Maluchenko, Natalya V. Feofanov, Alexey V. Studitsky, Vasily M. Int J Mol Sci Review Poly (ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme involved in processes of cell cycle regulation, DNA repair, transcription, and replication. Hyperactivity of PARP-1 induced by changes in cell homeostasis promotes development of chronic pathological processes leading to cell death during various metabolic disorders, cardiovascular and neurodegenerative diseases. In contrast, tumor growth is accompanied by a moderate activation of PARP-1 that supports survival of tumor cells due to enhancement of DNA lesion repair and resistance to therapy by DNA damaging agents. That is why PARP inhibitors (PARPi) are promising agents for the therapy of tumor and metabolic diseases. A PARPi family is rapidly growing partly due to natural polyphenols discovered among plant secondary metabolites. This review describes mechanisms of PARP-1 participation in the development of various pathologies, analyzes multiple PARP-dependent pathways of cell degeneration and death, and discusses representative plant polyphenols, which can inhibit PARP-1 directly or suppress unwanted PARP-dependent cellular processes. MDPI 2021-10-23 /pmc/articles/PMC8584120/ /pubmed/34768872 http://dx.doi.org/10.3390/ijms222111441 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Maluchenko, Natalya V. Feofanov, Alexey V. Studitsky, Vasily M. PARP-1-Associated Pathological Processes: Inhibition by Natural Polyphenols |
title | PARP-1-Associated Pathological Processes: Inhibition by Natural Polyphenols |
title_full | PARP-1-Associated Pathological Processes: Inhibition by Natural Polyphenols |
title_fullStr | PARP-1-Associated Pathological Processes: Inhibition by Natural Polyphenols |
title_full_unstemmed | PARP-1-Associated Pathological Processes: Inhibition by Natural Polyphenols |
title_short | PARP-1-Associated Pathological Processes: Inhibition by Natural Polyphenols |
title_sort | parp-1-associated pathological processes: inhibition by natural polyphenols |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584120/ https://www.ncbi.nlm.nih.gov/pubmed/34768872 http://dx.doi.org/10.3390/ijms222111441 |
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