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PARP-1-Associated Pathological Processes: Inhibition by Natural Polyphenols

Poly (ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme involved in processes of cell cycle regulation, DNA repair, transcription, and replication. Hyperactivity of PARP-1 induced by changes in cell homeostasis promotes development of chronic pathological processes leading to cell death during v...

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Detalles Bibliográficos
Autores principales: Maluchenko, Natalya V., Feofanov, Alexey V., Studitsky, Vasily M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584120/
https://www.ncbi.nlm.nih.gov/pubmed/34768872
http://dx.doi.org/10.3390/ijms222111441
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author Maluchenko, Natalya V.
Feofanov, Alexey V.
Studitsky, Vasily M.
author_facet Maluchenko, Natalya V.
Feofanov, Alexey V.
Studitsky, Vasily M.
author_sort Maluchenko, Natalya V.
collection PubMed
description Poly (ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme involved in processes of cell cycle regulation, DNA repair, transcription, and replication. Hyperactivity of PARP-1 induced by changes in cell homeostasis promotes development of chronic pathological processes leading to cell death during various metabolic disorders, cardiovascular and neurodegenerative diseases. In contrast, tumor growth is accompanied by a moderate activation of PARP-1 that supports survival of tumor cells due to enhancement of DNA lesion repair and resistance to therapy by DNA damaging agents. That is why PARP inhibitors (PARPi) are promising agents for the therapy of tumor and metabolic diseases. A PARPi family is rapidly growing partly due to natural polyphenols discovered among plant secondary metabolites. This review describes mechanisms of PARP-1 participation in the development of various pathologies, analyzes multiple PARP-dependent pathways of cell degeneration and death, and discusses representative plant polyphenols, which can inhibit PARP-1 directly or suppress unwanted PARP-dependent cellular processes.
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spelling pubmed-85841202021-11-12 PARP-1-Associated Pathological Processes: Inhibition by Natural Polyphenols Maluchenko, Natalya V. Feofanov, Alexey V. Studitsky, Vasily M. Int J Mol Sci Review Poly (ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme involved in processes of cell cycle regulation, DNA repair, transcription, and replication. Hyperactivity of PARP-1 induced by changes in cell homeostasis promotes development of chronic pathological processes leading to cell death during various metabolic disorders, cardiovascular and neurodegenerative diseases. In contrast, tumor growth is accompanied by a moderate activation of PARP-1 that supports survival of tumor cells due to enhancement of DNA lesion repair and resistance to therapy by DNA damaging agents. That is why PARP inhibitors (PARPi) are promising agents for the therapy of tumor and metabolic diseases. A PARPi family is rapidly growing partly due to natural polyphenols discovered among plant secondary metabolites. This review describes mechanisms of PARP-1 participation in the development of various pathologies, analyzes multiple PARP-dependent pathways of cell degeneration and death, and discusses representative plant polyphenols, which can inhibit PARP-1 directly or suppress unwanted PARP-dependent cellular processes. MDPI 2021-10-23 /pmc/articles/PMC8584120/ /pubmed/34768872 http://dx.doi.org/10.3390/ijms222111441 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Maluchenko, Natalya V.
Feofanov, Alexey V.
Studitsky, Vasily M.
PARP-1-Associated Pathological Processes: Inhibition by Natural Polyphenols
title PARP-1-Associated Pathological Processes: Inhibition by Natural Polyphenols
title_full PARP-1-Associated Pathological Processes: Inhibition by Natural Polyphenols
title_fullStr PARP-1-Associated Pathological Processes: Inhibition by Natural Polyphenols
title_full_unstemmed PARP-1-Associated Pathological Processes: Inhibition by Natural Polyphenols
title_short PARP-1-Associated Pathological Processes: Inhibition by Natural Polyphenols
title_sort parp-1-associated pathological processes: inhibition by natural polyphenols
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584120/
https://www.ncbi.nlm.nih.gov/pubmed/34768872
http://dx.doi.org/10.3390/ijms222111441
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