Chenodeoxycholic Acid Has Non-Thermogenic, Mitodynamic Anti-Obesity Effects in an In Vitro CRISPR/Cas9 Model of Bile Acid Receptor TGR5 Knockdown

Bile acids (BA) have shown promising effects in animal models of obesity. However, the said effects are thought to rely on a thermogenic effect, which is questionably present in humans. A previous work has shown that the BA chenodeoxycholic acid (CDCA) can revert obesity and accelerate metabolism in...

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Detalles Bibliográficos
Autores principales: Teodoro, João S., Machado, Ivo F., Castela, Ana C., Amorim, João A., Jarak, Ivana, Carvalho, Rui A., Palmeira, Carlos M., Rolo, Anabela P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584144/
https://www.ncbi.nlm.nih.gov/pubmed/34769169
http://dx.doi.org/10.3390/ijms222111738

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584144/
https://www.ncbi.nlm.nih.gov/pubmed/34769169
http://dx.doi.org/10.3390/ijms222111738

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