Combination of the Glutaminyl Cyclase Inhibitor PQ912 (Varoglutamstat) and the Murine Monoclonal Antibody PBD-C06 (m6) Shows Additive Effects on Brain Aβ Pathology in Transgenic Mice

Compelling evidence suggests that pyroglutamate-modified Aβ (pGlu3-Aβ; AβN3pG) peptides play a pivotal role in the development and progression of Alzheimer’s disease (AD). Approaches targeting pGlu3-Aβ by glutaminyl cyclase (QC) inhibition (Varoglutamstat) or monoclonal antibodies (Donanemab) are cu...

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Detalles Bibliográficos
Autores principales: Hoffmann, Torsten, Rahfeld, Jens-Ulrich, Schenk, Mathias, Ponath, Falk, Makioka, Koki, Hutter-Paier, Birgit, Lues, Inge, Lemere, Cynthia A., Schilling, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584206/
https://www.ncbi.nlm.nih.gov/pubmed/34769222
http://dx.doi.org/10.3390/ijms222111791

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584206/
https://www.ncbi.nlm.nih.gov/pubmed/34769222
http://dx.doi.org/10.3390/ijms222111791

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