Long-Chain and Very Long-Chain Ceramides Mediate Doxorubicin-Induced Toxicity and Fibrosis

Doxorubicin (Dox) is a chemotherapeutic agent with cardiotoxicity associated with profibrotic effects. Dox increases ceramide levels with pro-inflammatory effects, cell death, and fibrosis. The purpose of our study was to identify the underlying ceramide signaling pathways. We aimed to characterize...

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Detalles Bibliográficos
Autores principales: Kretzschmar, Tom, Bekhite, Mohamed M., Wu, Jasmine M. F., Haase, Daniela, Förster, Martin, Müller, Tina, Nietzsche, Sandor, Westermann, Martin, Franz, Marcus, Gräler, Markus H., Schulze, P. Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584314/
https://www.ncbi.nlm.nih.gov/pubmed/34769283
http://dx.doi.org/10.3390/ijms222111852

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584314/
https://www.ncbi.nlm.nih.gov/pubmed/34769283
http://dx.doi.org/10.3390/ijms222111852

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