Development of In Vitro and In Vivo Evaluation Systems for Vitamin D Derivatives and Their Application to Drug Discovery

We have developed an in vitro system to easily examine the affinity for vitamin D receptor (VDR) and CYP24A1-mediated metabolism as two methods of assessing vitamin D derivatives. Vitamin D derivatives with high VDR affinity and resistance to CYP24A1-mediated metabolism could be good therapeutic age...

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Detalles Bibliográficos
Autores principales: Yasuda, Kaori, Nishikawa, Miyu, Mano, Hiroki, Takano, Masashi, Kittaka, Atsushi, Ikushiro, Shinichi, Sakaki, Toshiyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584323/
https://www.ncbi.nlm.nih.gov/pubmed/34769269
http://dx.doi.org/10.3390/ijms222111839

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584323/
https://www.ncbi.nlm.nih.gov/pubmed/34769269
http://dx.doi.org/10.3390/ijms222111839

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