Synthesis of Novel 2-Thiouracil-5-Sulfonamide Derivatives as Potent Inducers of Cell Cycle Arrest and CDK2A Inhibition Supported by Molecular Docking

In an effort to discover potent anticancer agents, 2-thiouracil-5-sulfonamides derivatives were designed and synthesized. The cytotoxic activity of all synthesized compounds was investigated against four human cancer cell lines viz A-2780 (ovarian), HT-29 (colon), MCF-7 (breast), and HepG2 (liver)....

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Detalles Bibliográficos
Autores principales: Fatahala, Samar S., Sayed, Amira I., Mahgoub, Shahenda, Taha, Heba, El-Sayed, Mohamed-I kotb, El-Shehry, Mohamed F., Awad, Samir M., Abd El-Hameed, Rania H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584424/
https://www.ncbi.nlm.nih.gov/pubmed/34769385
http://dx.doi.org/10.3390/ijms222111957

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584424/
https://www.ncbi.nlm.nih.gov/pubmed/34769385
http://dx.doi.org/10.3390/ijms222111957

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