Model Identifies Genetic Predisposition of Alzheimer’s Disease as Key Decider in Cell Susceptibility to Stress

Accumulation of unfolded/misfolded proteins in neuronal cells perturbs endoplasmic reticulum homeostasis, triggering a stress cascade called unfolded protein response (UPR), markers of which are upregulated in Alzheimer’s disease (AD) brain specimens. We measured the UPR dynamic response in three hu...

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Detalles Bibliográficos
Autores principales: Stefani, Ioanna C., de Thé, François-Xavier Blaudin, Kontoravdi, Cleo, Polizzi, Karen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584528/
https://www.ncbi.nlm.nih.gov/pubmed/34769426
http://dx.doi.org/10.3390/ijms222112001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584528/
https://www.ncbi.nlm.nih.gov/pubmed/34769426
http://dx.doi.org/10.3390/ijms222112001

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