Expression of Human Mutant Preproinsulins Induced Unfolded Protein Response, Gadd45 Expression, JAK-STAT Activation, and Growth Inhibition in Drosophila

Mutations in the insulin gene (INS) are frequently associated with human permanent neonatal diabetes mellitus. However, the mechanisms underlying the onset of this genetic disease is not sufficiently decoded. We induced expression of two types of human mutant INSs in Drosophila using its ectopic exp...

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Detalles Bibliográficos
Autores principales: Yamazoe, Tatsuki, Nakahara, Yasuyuki, Katsube, Hiroka, Inoue, Yoshihiro H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584581/
https://www.ncbi.nlm.nih.gov/pubmed/34769468
http://dx.doi.org/10.3390/ijms222112038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584581/
https://www.ncbi.nlm.nih.gov/pubmed/34769468
http://dx.doi.org/10.3390/ijms222112038

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