The Fibrotic Effects of TMAO on Human Renal Fibroblasts Is Mediated by NLRP3, Caspase-1 and the PERK/Akt/mTOR Pathway

Trimethylamine N-oxide (TMAO), a product of gut microbiota metabolism, has previously been shown to be implicated in chronic kidney disease. A high TMAO-containing diet has been found to cause tubulointerstitial renal fibrosis in mice. However, today there are no data linking specific molecular path...

Descripción completa

Detalles Bibliográficos
Autores principales: Kapetanaki, Stefania, Kumawat, Ashok Kumar, Persson, Katarina, Demirel, Isak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584593/
https://www.ncbi.nlm.nih.gov/pubmed/34769294
http://dx.doi.org/10.3390/ijms222111864

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584593/
https://www.ncbi.nlm.nih.gov/pubmed/34769294
http://dx.doi.org/10.3390/ijms222111864

Ejemplares similares