Cargando…

Induction of Premature Cell Senescence Stimulated by High Doses of Antioxidants Is Mediated by Endoplasmic Reticulum Stress

In our previous study, we found that high doses of several substances with antioxidant capacities (Tempol, resveratrol, diphenyleneiodonium) can cause genotoxic stress and induce premature senescence in the human mesenchymal stem cells (MSCs). Here, using whole-transcriptome analysis, we revealed th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lyublinskaya, Olga, Kornienko, Julia, Ivanova, Julia, Pugovkina, Natalia, Alekseenko, Larisa, Lyublinskaya, Ekaterina, Tyuryaeva, Irina, Smirnova, Irina, Grinchuk, Tatiana, Shorokhova, Mariia, Krasnenko, Anna, Plotnikov, Nikolay, Nikolsky, Nikolay
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584632/ https://www.ncbi.nlm.nih.gov/pubmed/34769282 http://dx.doi.org/10.3390/ijms222111851

Ejemplares similares

Impact of Polyallylamine Hydrochloride on Gene Expression and Karyotypic Stability of Multidrug Resistant Transformed Cells
por: Alekseenko, Larisa, et al.
Publicado: (2020)

Three-Dimensional Compaction Switches Stress Response Programs and Enhances Therapeutic Efficacy of Endometrial Mesenchymal Stem/Stromal Cells
por: Domnina, Alisa, et al.
Publicado: (2020)

Generation of Therapeutically Potent Spheroids from Human Endometrial Mesenchymal Stem/Stromal Cells
por: Domnina, Alisa, et al.
Publicado: (2021)

High doses of synthetic antioxidants induce premature senescence in cultivated mesenchymal stem cells
por: Kornienko, Ju. S., et al.
Publicado: (2019)

Resistance to H(2)O(2)-induced oxidative stress in human cells of different phenotypes
por: Zenin, Valeriy, et al.
Publicado: (2022)

Human mesenchymal stem cells in spheroids improve fertility in model animals with damaged endometrium
por: Domnina, Alisa, et al.
Publicado: (2018)

Chromothripsis—Explosion in Genetic Science
por: Shorokhova, Mariia, et al.
Publicado: (2021)

Expected and Unexpected Effects of Pharmacological Antioxidants
por: Tyuryaeva, Irina, et al.
Publicado: (2023)

Outcomes of Deferoxamine Action on H(2)O(2)-Induced Growth Inhibition and Senescence Progression of Human Endometrial Stem Cells
por: Shatrova, Alla N., et al.
Publicado: (2021)

Paracrine and Autocrine Effects of VEGF Are Enhanced in Human eMSC Spheroids
por: Kozhukharova, Irina, et al.
Publicado: (2022)

Quiescent Human Mesenchymal Stem Cells Are More Resistant to Heat Stress than Cycling Cells
por: Alekseenko, L. L., et al.
Publicado: (2018)

Origin of anti-tumor activity of the cysteine-containing GO peptides and further optimization of their cytotoxic properties
por: Tyuryaeva, Irina I., et al.
Publicado: (2017)

Redox Homeostasis and Regulation in Pluripotent Stem Cells: Uniqueness or Versatility?
por: Ivanova, Julia S., et al.
Publicado: (2021)

Mesenchymal stem cells with irreversibly arrested proliferation stimulate decidua development in rats
por: Domnina, Alisa P., et al.
Publicado: (2016)

Cell Cycle-Dependent Expression of Bk Channels in Human Mesenchymal Endometrial Stem Cells
por: Chubinskiy-Nadezhdin, Vladislav I., et al.
Publicado: (2019)

Monovalent ions and stress-induced senescence in human mesenchymal endometrial stem/stromal cells
por: Shatrova, Alla, et al.
Publicado: (2022)

Sublethal Oxidative Stress Induces the Premature Senescence of Human Mesenchymal Stem Cells Derived from Endometrium
por: Burova, Elena, et al.
Publicado: (2013)

Redox environment in stem and differentiated cells: A quantitative approach
por: Lyublinskaya, O.G., et al.
Publicado: (2017)

Cytogenetic and Transcriptomic Analysis of Human Endometrial MSC Retaining Proliferative Activity after Sublethal Heat Shock
por: Shilina, Mariia A., et al.
Publicado: (2018)

Proliferation-related changes in K(+) content in human mesenchymal stem cells
por: Marakhova, Irina, et al.
Publicado: (2019)

Reactive Oxygen Species Are Required for Human Mesenchymal Stem Cells to Initiate Proliferation after the Quiescence Exit
por: Lyublinskaya, O. G., et al.
Publicado: (2015)

Mesenchymal Stem/Stromal Cells in Three-Dimensional Cell Culture: Ion Homeostasis and Ouabain-Induced Apoptosis
por: Shatrova, Alla N., et al.
Publicado: (2023)

Measuring intracellular concentration of hydrogen peroxide with the use of genetically encoded H(2)O(2) biosensor HyPer
por: Lyublinskaya, Olga, et al.
Publicado: (2019)

Molecular Genetic Analysis of Human Endometrial Mesenchymal Stem Cells That Survived Sublethal Heat Shock
por: Vinogradov, A. E., et al.
Publicado: (2017)

Senescent Changes and Endoplasmic Reticulum Stress May Be Involved in the Pathogenesis of Missed Miscarriage
por: Tang, Yunhui, et al.
Publicado: (2021)

Iron oxide nanoparticles trigger endoplasmic reticulum damage in steatotic hepatic cells
por: Uzhytchak, Mariia, et al.
Publicado: (2023)

THE ENDOPLASMIC RETICULUM
por: Palade, George E.
Publicado: (1956)

Paracrine senescence of human endometrial mesenchymal stem cells: a role for the insulin-like growth factor binding protein 3
por: Vassilieva, Irina, et al.
Publicado: (2020)

The Role of Endoplasmic Reticulum Stress and Unfolded Protein Response in Atherosclerosis
por: Ivanova, Ekaterina A., et al.
Publicado: (2016)

Interaction between ROS dependent DNA damage, mitochondria and p38 MAPK underlies senescence of human adult stem cells
por: Borodkina, Aleksandra, et al.
Publicado: (2014)

The Role of Endoplasmic Reticulum Stress in Differentiation of Cells of Mesenchymal Origin
por: Turishcheva, Ekaterina, et al.
Publicado: (2022)

P38 MAPK inhibition prevents polybrene-induced senescence of human mesenchymal stem cells during viral transduction
por: Griukova, Anastasiia, et al.
Publicado: (2018)

Molecular basis of senescence transmitting in the population of human endometrial stromal cells
por: Griukova, Anastasiia, et al.
Publicado: (2019)

Construction of the endoplasmic reticulum
Publicado: (1989)

Time-Dependent Regulation of IL-2R α-Chain (CD25) Expression by TCR Signal Strength and IL-2-Induced STAT5 Signaling in Activated Human Blood T Lymphocytes
por: Shatrova, Alla N., et al.
Publicado: (2016)

Activation of endoplasmic reticulum stress in premature aging via the inner nuclear membrane protein SUN2
por: Vidak, Sandra, et al.
Publicado: (2023)

Endoplasmic Reticulum Stress Plays a Key Role in the Pathogenesis of Diabetic Peripheral Neuropathy
por: Lupachyk, Sergey, et al.
Publicado: (2013)

Osteoblastic Swedish mutant APP expedites brain deficits by inducing endoplasmic reticulum stress-driven senescence
por: Pan, Jin-Xiu, et al.
Publicado: (2021)

Paxlovid accelerates cartilage degeneration and senescence through activating endoplasmic reticulum stress and interfering redox homeostasis
por: Kong, Keyu, et al.
Publicado: (2022)

Simultaneous Measurement of Changes in Mitochondrial and Endoplasmic Reticulum Free Calcium in Pancreatic Beta Cells
por: Jeyarajan, Sivakumar, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_h7m0ns8eiqlfh9335njoqutnrb