A behavioral screen for mediators of age-dependent TDP-43 neurodegeneration identifies SF2/SRSF1 among a group of potent suppressors in both neurons and glia

Cytoplasmic aggregation of Tar-DNA/RNA binding protein 43 (TDP-43) occurs in 97 percent of amyotrophic lateral sclerosis (ALS), ~40% of frontotemporal dementia (FTD) and in many cases of Alzheimer’s disease (AD). Cytoplasmic TDP-43 inclusions are seen in both sporadic and familial forms of these dis...

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Detalles Bibliográficos
Autores principales: Azpurua, Jorge, El-Karim, Enas Gad, Tranquille, Marvel, Dubnau, Josh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584670/
https://www.ncbi.nlm.nih.gov/pubmed/34723963
http://dx.doi.org/10.1371/journal.pgen.1009882

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584670/
https://www.ncbi.nlm.nih.gov/pubmed/34723963
http://dx.doi.org/10.1371/journal.pgen.1009882

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