Positive correlation between transcriptomic stemness and PI3K/AKT/mTOR signaling scores in breast cancer, and a counterintuitive relationship with PIK3CA genotype

A PI3Kα-selective inhibitor has recently been approved for use in breast tumors harboring mutations in PIK3CA, the gene encoding p110α. Preclinical studies have suggested that the PI3K/AKT/mTOR signaling pathway influences stemness, a dedifferentiation-related cellular phenotype associated with aggr...

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Detalles Bibliográficos
Autores principales: Madsen, Ralitsa R., Erickson, Emily C., Rueda, Oscar M., Robin, Xavier, Caldas, Carlos, Toker, Alex, Semple, Robert K., Vanhaesebroeck, Bart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584750/
https://www.ncbi.nlm.nih.gov/pubmed/34762647
http://dx.doi.org/10.1371/journal.pgen.1009876

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584750/
https://www.ncbi.nlm.nih.gov/pubmed/34762647
http://dx.doi.org/10.1371/journal.pgen.1009876

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