Cargando…

Inhibitors of the Sec61 Complex and Novel High Throughput Screening Strategies to Target the Protein Translocation Pathway

Proteins targeted to the secretory pathway start their intracellular journey by being transported across biological membranes such as the endoplasmic reticulum (ER). A central component in this protein translocation process across the ER is the Sec61 translocon complex, which is only intracellularly...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pauwels, Eva, Schülein, Ralf, Vermeire, Kurt
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585047/ https://www.ncbi.nlm.nih.gov/pubmed/34769437 http://dx.doi.org/10.3390/ijms222112007

Ejemplares similares

Use of a sequential high throughput screening assay to identify novel inhibitors of the eukaryotic SRP-Sec61 targeting/translocation pathway
por: Klein, Wolfgang, et al.
Publicado: (2018)

Role of the Cytoplasmic Segments of Sec61α in the Ribosome-Binding and Translocation-Promoting Activities of the Sec61 Complex
por: Raden, David, et al.
Publicado: (2000)

Structural insights into TRAP association with ribosome-Sec61 complex and translocon inhibition by a CADA derivative
por: Pauwels, Eva, et al.
Publicado: (2023)

A Proteomic Study on the Membrane Protein Fraction of T Cells Confirms High Substrate Selectivity for the ER Translocation Inhibitor Cyclotriazadisulfonamide
por: Pauwels, Eva, et al.
Publicado: (2021)

Complexity and Specificity of Sec61-Channelopathies: Human Diseases Affecting Gating of the Sec61 Complex
por: Sicking, Mark, et al.
Publicado: (2021)

Cotranslational Folding Inhibits Translocation from Within the Ribosome–Sec61 Translocon Complex
por: Conti, Brian J., et al.
Publicado: (2014)

Sec61β, a subunit of the Sec61 protein translocation channel at the Endoplasmic Reticulum, is involved in the transport of Gurken to the plasma membrane.
por: Kelkar, Anshuman, et al.
Publicado: (2009)

Sec61 channel subunit Sbh1/Sec61β promotes ER translocation of proteins with suboptimal targeting sequences and is fine-tuned by phosphorylation
por: Barbieri, Guido, et al.
Publicado: (2023)

Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation
por: Zong, Guanghui, et al.
Publicado: (2019)

Mammalian SRP receptor switches the Sec61 translocase from Sec62 to SRP-dependent translocation
por: Jadhav, Bhalchandra, et al.
Publicado: (2015)

Reduced DNAJC3 Expression Affects Protein Translocation across the ER Membrane and Attenuates the Down-Modulating Effect of the Translocation Inhibitor Cyclotriazadisulfonamide
por: Pauwels, Eva, et al.
Publicado: (2022)

Sec61p Is Required for ERAD-L: GENETIC DISSECTION OF THE TRANSLOCATION AND ERAD-L FUNCTIONS OF Sec61P USING NOVEL DERIVATIVES OF CPY
por: Willer, Martin, et al.
Publicado: (2008)

Functional characterization of the trans-membrane domain interactions of the Sec61 protein translocation complex beta-subunit
por: Zhao, Xueqiang, et al.
Publicado: (2009)

The β Subunit of the Sec61 Complex Facilitates Cotranslational Protein Transport and Interacts with the Signal Peptidase during Translocation
por: Kalies, Kai-Uwe, et al.
Publicado: (1998)

Identification of cytoplasmic residues of Sec61p involved in ribosome binding and cotranslational translocation
por: Cheng, Zhiliang, et al.
Publicado: (2005)

Mechanistic insights into the inhibition of Sec61-dependent co- and post-translational translocation by mycolactone
por: McKenna, Michael, et al.
Publicado: (2016)

Loopy Sec61 mutants
por: LeBrasseur, Nicole
Publicado: (2005)

Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62
por: Itskanov, Samuel, et al.
Publicado: (2021)

Sec61 in antigen cross-presentation
por: Zehner, Matthias, et al.
Publicado: (2015)

Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier
por: Haßdenteufel, Sarah, et al.
Publicado: (2018)

How does Sec63 affect the conformation of Sec61 in yeast?
por: Bhadra, Pratiti, et al.
Publicado: (2021)

Inhibitors of protein translocation across membranes of the secretory pathway: novel antimicrobial and anticancer agents
por: Van Puyenbroeck, Victor, et al.
Publicado: (2018)

Cholera Toxin Is Exported from Microsomes by the Sec61p Complex
por: Schmitz, Anton, et al.
Publicado: (2000)

Disulfide bridge formation between SecY and a translocating polypeptide localizes the translocation pore to the center of SecY
por: Cannon, Kurt S., et al.
Publicado: (2005)

Let’s talk about Secs: Sec61, Sec62 and Sec63 in signal transduction, oncology and personalized medicine
por: Linxweiler, Maximilian, et al.
Publicado: (2017)

An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate
por: MacKinnon, Andrew L, et al.
Publicado: (2014)

Binding of ribosomes to the rough endoplasmic reticulum mediated by the Sec61p-complex
Publicado: (1994)

Structure of the Mammalian Ribosome-Sec61 Complex to 3.4 Å Resolution
por: Voorhees, Rebecca M., et al.
Publicado: (2014)

Stage- and ribosome-specific alterations in nascent chain-Sec61p interactions accompany translocation across the ER membrane
Publicado: (1995)

Copper inhibits protein maturation in the secretory pathway by targeting the Sec61 translocon in Saccharomyces cerevisiae
por: Saha, Nitu, et al.
Publicado: (2022)

Mobility of the SecA 2-helix-finger is not essential for polypeptide translocation via the SecYEG complex
por: Whitehouse, Sarah, et al.
Publicado: (2012)

Structure of the native Sec61 protein-conducting channel
por: Pfeffer, Stefan, et al.
Publicado: (2015)

MoSec61β, the beta subunit of Sec61, is involved in fungal development and pathogenicity, plant immunity, and ER-phagy in Magnaporthe oryzae
por: Wei, Yun-Yun, et al.
Publicado: (2020)

Mycolactone reveals the substrate-driven complexity of Sec61-dependent transmembrane protein biogenesis
por: McKenna, Michael, et al.
Publicado: (2017)

SEC61G Promotes Cervical Cancer Proliferation by Activating MAPK Signaling Pathway
por: Fan, Yangyang, et al.
Publicado: (2022)

Sec61 blockade therapy overrides resistance to proteasome inhibitors and immunomodulatory drugs in multiple myeloma
por: Domenger, Antoine, et al.
Publicado: (2023)

Mycolactone subverts immunity by selectively blocking the Sec61 translocon
por: Baron, Ludivine, et al.
Publicado: (2016)

An Update on Sec61 Channel Functions, Mechanisms, and Related Diseases
por: Lang, Sven, et al.
Publicado: (2017)

The Sec61 translocon is a therapeutic vulnerability in multiple myeloma
por: Domenger, Antoine, et al.
Publicado: (2022)

Reorientation of the first signal-anchor sequence during potassium channel biogenesis at the Sec61 complex
por: Watson, Helen R., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_h2vhcli1pf2c3lbae6fo492kq9