Insights into Intra-Tumoral Heterogeneity: Transcriptional Profiling of Chemoresistant MPM Cell Subpopulations Reveals Involvement of NFkB and DNA Repair Pathways and Contributes a Prognostic Signature

Chemoresistance is a hallmark of malignant pleural mesothelioma (MPM) management and the expression of ALDH1A3 is responsible for the survival and activity of MPM chemoresistant cell subpopulations (ALDH(bright) cells). We enriched mesothelioma ALDH(bright) cells to near homogeneity by FACS sorting...

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Detalles Bibliográficos
Autores principales: Cioce, Mario, Sacconi, Andrea, Pass, Harvey I., Canino, Claudia, Strano, Sabrina, Blandino, Giovanni, Fazio, Vito Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585077/
https://www.ncbi.nlm.nih.gov/pubmed/34769499
http://dx.doi.org/10.3390/ijms222112071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585077/
https://www.ncbi.nlm.nih.gov/pubmed/34769499
http://dx.doi.org/10.3390/ijms222112071

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