RET signalling provides tumorigenic mechanism and tissue specificity for AIP-related somatotrophinomas

It is unclear how loss-of-function germline mutations in the widely-expressed co-chaperone AIP, result in young-onset growth hormone secreting pituitary tumours. The RET receptor, uniquely co-expressed in somatotrophs with PIT1, induces apoptosis when unliganded, while RET supports cell survival whe...

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Detalles Bibliográficos
Autores principales: Garcia-Rendueles, Angela R., Chenlo, Miguel, Oroz-Gonjar, Fernando, Solomou, Antonia, Mistry, Anisha, Barry, Sayka, Gaston-Massuet, Carles, Garcia-Lavandeira, Montserrat, Perez-Romero, Sihara, Suarez-Fariña, Maria, Pradilla-Dieste, Alberto, Dieguez, Carlos, Mehlen, Patrick, Korbonits, Márta, Alvarez, Clara V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585666/
https://www.ncbi.nlm.nih.gov/pubmed/34588620
http://dx.doi.org/10.1038/s41388-021-02009-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585666/
https://www.ncbi.nlm.nih.gov/pubmed/34588620
http://dx.doi.org/10.1038/s41388-021-02009-8

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